Moderate Crescent Formation Does Not Correlate with IgA Nephropathy Progression

TWEAK/Fn14 system and crescent formation in IgA nephropathy

BACKGROUND The TNF-like weak inducer of apoptosis (TWEAK) contributes to kidney inflammation producing secretion by renal cells. The present study examined whether the level of TWEAK is associated with histologic findings in patients with IgA nephropathy (IgAN). METHODS The levels of urinary TWEAK (uTWEAK) from 116 IgAN patients, 50 non-IgA kidney disease patients, and 50 healthy individuals ...

Clinical Pathological Analysis and Treatment of Iga Nephropathy with a Few Quantity of Renal Crescent Formation

Background: IgA nephropathy was a syndrome of uniform morphology, diverse clinical features and uncertain prognosis, presence of crescents around blood vessels indices the unfavorable long-term prognosis, if the proportion of crescent in glomeruli exceeding ratio of 50%, we give the active treatment of prednisone pulse therapy, but in most condition, IgA nephropathy was diagnosed with a few of ...

Modulating the progression in IgA nephropathy.

IgA nephropathy affects almost 1% of the population and yet the diagnosis is often missed. This significant kidney disease is often progressive with 25% of the patients going on to end-stage kidney disease over the course of 25 years. This minireview describes the clinical presentations in children and young adults. Therapeutic options are discussed including angiotensin-converting enzyme block...

Does circulating erythropoietin reflect progression of IgA nephropathy? Comparison with urinary N-acetyl-beta-D-glucosaminidase.

BACKGROUND Recent reports describe that erythropoietin (Epo) is produced by peritubular interstitial fibroblast-like cells in response to a hypoxic stimulus. We studied serum Epo levels as a possible marker of tubulointerstitial damage in the progression of IgA nephropathy (IgAN), in comparison with urinary (u-) levels of N-acetyl-beta-D-glucosaminidase (NAG), which is mainly derived from proxi...

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